Our Capabilities
Process R&D Strength
- Synthetic route scouting – Novel, non-infringing, quicker, more dependable, and cost-effective
- Optimizing the process to have robust In-process control and scalable process.
- Technology transfer to manufacturing sites
- Quick process development to provide proof of concept.
- Process validation and scale-up studies
- Preparation of standards samples & impurities
- Stability testing and Degradation studies
- Solid state studies (polymorphism)
- Carbohydrate chemistry, Amino acid chemistry, Asymmetric synthesis
- Bio-transformations
- Suzuki Coupling, Heck Coupling & Sonogashira Coupling
- Catalytic hydrogenation, Hydroxymethylation, Grignard reaction
- Preparation Phase Transfer Catalyst, Nitration & etherification
- Multi-step chiral synthesis and Chiral resolution
- Heterocycles
- Suzuki Coupling, Heck Coupling, Buchwald – Hartwig Coupling, and Sonogashira Coupling
- Bromination & Thiazole formation
- Borane / Diborane chemistry
- Natural products, Nucleosides & Nucleotides
Analytical R&D Strengths
- Method development (Chemical & Chiral)
- Methods validations (Chemical & Chiral)
- Specification development
- Impurity profiling
- Structure elucidation with relevant spectroscopic analysis
- Chemical & Chiral purifications by prep. HPLC from milligrams to kilograms scales
- Product characterization by NMR, IR, LCMS
- Solid state characterization by XRD, DSC, IR
- Stability and degradation studies
- Qualification of working standards/Reference standards
- CMC documentation support for regulatory filings.
Manufacturing R&D Strengths
- Capacity to produce up to 50kg from in-house cGMP pilot plant and 5-10 metric tons per month from our partner/associated manufacturing plants.
- Handling of the air/moisture sensitive reagents (Grignard, Friedel crafts acylation, n-BuLi, Sonogashira couplings and silylation reactions), Reducing agents (LAH, NaBH4, etc.), Pyrophoric chemicals (Sodium hydride, Raney Ni, etc.) and Pressure reactions (10-18kg/cm2)
- Homogenous and Heterogeneous Hydrogenation reactions
- Pressure reactions (10-18kg/cm2) and Temperature ranges from -70 to +200 deg C
- CMC documentation support for regulatory filings.