Our Capabilities

Process R&D Strength

Synthetic route scouting – Novel, non-infringing, quicker, more dependable, and cost-effective
Optimizing the process to have robust In-process control and scalable process.
Technology transfer to manufacturing sites
Quick process development to provide proof of concept.
Process validation and scale-up studies
Preparation of standards samples & impurities
Stability testing and Degradation studies
Solid state studies (polymorphism)
Carbohydrate chemistry, Amino acid chemistry, Asymmetric synthesis

Bio-transformations
Suzuki Coupling, Heck Coupling & Sonogashira Coupling
Catalytic hydrogenation, Hydroxymethylation, Grignard reaction
Preparation Phase Transfer Catalyst, Nitration & etherification
Multi-step chiral synthesis and Chiral resolution
Heterocycles
Suzuki Coupling, Heck Coupling, Buchwald – Hartwig Coupling, and Sonogashira Coupling
Bromination & Thiazole formation
Borane / Diborane chemistry
Natural products, Nucleosides & Nucleotides

Method development (Chemical & Chiral)
Methods validations (Chemical & Chiral)
Specification development
Impurity profiling
Structure elucidation with relevant spectroscopic analysis
Chemical & Chiral purifications by prep. HPLC from milligrams to kilograms scales

Capacity to produce up to 50kg from in-house cGMP pilot plant and 5-10 metric tons per month from our partner/associated manufacturing plants.
Handling of the air/moisture sensitive reagents (Grignard, Friedel crafts acylation, n-BuLi, Sonogashira couplings and silylation reactions), Reducing agents (LAH, NaBH4, etc.), Pyrophoric chemicals (Sodium hydride, Raney Ni, etc.) and Pressure reactions (10-18kg/cm2)
Homogenous and Heterogeneous Hydrogenation reactions
Pressure reactions (10-18kg/cm2) and Temperature ranges from -70 to +200 deg C
CMC documentation support for regulatory filings.